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[17] Additionally, the FDA has raised concerns over the lack of data to determine if the long-acting once-weekly version of exenatide (but not the twice-daily form of exenatide) may increase thyroid cancer risk

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We noted that Semaglutide and Dulaglutide, for which the residence times were shorter than other compounds and also induced modestly increased recycling, were closest to ex-phe1 in this insulin release assay (albeit consistently less efficacious)