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69–73 Global phase III clinical trials conducted to evaluate the efficacy and safety of weekly tirzepatide included anti-hyperglycaemic therapy-naive patients and patients on various oral anti-hyperglycaemic drugs, including metformin, sulfonylurea, pioglitazone, SGLT2 inhibitor and/or insulin compared with placebo, basal insulins, or the conventional GLP-1R agonist ( Tables 1 and 2 , Figure 4 )
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