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Limited Long-term Data : While short- to medium-term data are compelling, the long-term safety and efficacy profile over decades of treatment remains incompletely characterized
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The PK profiles of intact AMG 133 (GIPR-Ab with at least one attached GLP-1 analogue peptide) and total AMG 133 (GIPR-Ab with or without GLP-1 analogue peptides) follow a biphasic clearance pattern and demonstrate similar initial concentrations between assays with a gradual divergence over the 2-week study period
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