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As a GLP-1 drug, semaglutide mimics the action of the natural GLP-1 gastrointestinal hormone

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We hypothesize that adding a long-acting GLP-1-RA can increase basal GLP-1 levels and, in combination with native post-prandial GLP-1 bolus restored after MBS, may be considered as a “basal-bolus” treatment for individuals with MBS failure (Fig