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In addition, murine models show that liraglutide can access specific brain areas relevant for appetite regulation, binding GLP-1 receptors on proopiomelanocortin and cocaine- and amphetamine-regulated transcript (POMC/CART)-expressing arcuate nucleus neurons [32]
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Interestingly, while it did not affect alcohol-induced CPP, it selectively suppressed hedonic feeding and enhanced novelty-seeking behavior, consistent with broader mesolimbic modulation [49]
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