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Indications Adjunct to diet and exercise to improve glycaemic control in adults with Type 2 Diabetes Mellitus Add-on therapy where metformin alone or metformin plus another oral antidiabetic provides inadequate control Reduction of major adverse cardiovascular events in adults with Type 2 Diabetes Mellitus and established cardiovascular disease Suitable for patients where a once-weekly injectable regimen improves adherence over daily therapy May be used in combination with metformin, sulphonylureas, SGLT2 inhibitors or basal insulin, per physician judgement Mechanism of Action Semaglutide is a long-acting analogue of human glucagon-like peptide-1 (GLP-1) sharing 94% sequence homology with the native hormone