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Frontiers | Tirzepatide vs. semaglutide for obesity, glycemic control, and cardiovascular outcomes: a narrative review of clinical trials

Animal studies conducted during drug development showed minimal detection of semaglutide in lactating rat milk, though human lactation studies remain limited

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Hypertension also directly contributes to increased filling pressures, and explains why HFpEF and AF in midlife are becoming more common and blood pressure reductions are beneficial [45,46]