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For those wondering about results without exercise, losing weight on semaglutide without exercise is possible, though outcomes tend to be better with at least some physical activity

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Purifications were conducted by preparative RP-HPLC, eluting with a linear gradient (20 ml min −1 ) and using a binary solvent system consisting of H 2 O:MeCN:TFA (buffer A, 95:5:0.1