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Naltrexone is Food and Drug Administration (FDA) approved for the treatment of AUD and opioid use disorder (OUD) and is also used as an antiobesity medication in the extended-release form when combined with bupropion [24]

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Statistics showed that PC1/3 and PC2 in Model group was significantly lower than that in Control group, and then increased after berberine treatment (Figures 4C, D)