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Patients with specific GLP1R genotypes, for example, may show enhanced semaglutide responsiveness, while those with GIPR variants may benefit from tirzepatide's dual GLP-1 and GIP receptor activation
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That experimental therapy combines GLP-1 and GIP with activation of nuclear hormone receptors known as PPARs — targets once used by diabetes drugs like rosiglitazone and pioglitazone
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