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In contrast, single injection of Tregs or IL-10 overexpressing engineered T cells promoted gene expression of chemokines/cytokines in microglia (Ccl2, Ccl7, and Cxcl10), regulated the chemotactic behavior of microglia and neural stem cells, promoted angiogenesis, and was speculated to contribute to the repair of ischemic injury ( On one hand, GLP-1RA could reduce the proliferation of effector T cells, promote the generation and function of Treg cells

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Additional studies confirmed that virus-mediated GLP-1R knockdown in rats and mice increased bodyweight, but found this occurred through decreased energy expenditure, not increased food intake (111, 112)