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“They are unlikely to improve with prolonged use,” says Fishman

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Yet 6 to 7 weeks of daily treatment with semaglutide (escalated from 41 μg/kg to 103 μg/kg) or tirzepatide (escalated from 12 μg/kg to 48 μg/kg) did not produce any noticeable effect on these readouts, including Iba-1 activation, in 12-month-old 5XFAD and APP/PS1 mice (51)