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FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss | FDA

Fatigue is a recognised adverse reaction in the product information for some GLP-1 medications, particularly those used at higher doses for weight management (such as semaglutide 2.4 mg and liraglutide 3 mg)

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However, irrespective of the HF subtype, patients with concurrent obesity are more likely to experience adverse hemodynamic profiles, more severe clinical manifestations, and overall reduced quality of life [8,9]