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Fluorescently labeled liraglutide reaches hypothalamic regions such as the ARC, paraventricular nucleus (PVH), and supraoptic nucleus (SON) after peripheral administration, with GLP-1R undergoing internalization after binding to liraglutide [57]
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4 Insulin resistance, weight gain, and infertility are common features of PCOS, and due to this, PCOS is considered a risk factor for developing type 2 diabetes, which has prompted some providers to use GLP-1 RAs in this patient population
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