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Meanwhile, a phase 2a clinical study among type 2 diabetes patients with CKD showed that MEDI0382 (50 to 300 μg) significantly reduced body weight by 3.41 kg, and urinary albumin-to-creatinine ratios by 51% versus placebo, suggesting that GLP-1R/GCGR dual agonism may offer additional benefits to CKD (44)