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Meanwhile, across the Atlantic, Novo Nordisk and other companies were busy engineering human GLP-1 analogues (like “NN2211,” which became liraglutide) using techniques such as acylation to extend half-life ( [89] ) ( [90] )
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One reason this happens is that the Big E has a hand in modulating two critical hunger-modulating hormones: ghrelin, which can rev up food intake, and leptin, the satiety (aka fullness) hormone
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