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Besides, in H9c2 cardiomyocytes, GLP-1RAs also inhibit hypoxia-induced NLRP3 inflammasome activity and TNF-α to attenuate pyroptosis through modulating the SIRT1/NADPH oxidase 4 (NOX4)/ROS pathway 139

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Retatrutide is a triple GLP-1/GIP/glucagon receptor agonist

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