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Clinicians began exploring this approach for a few reasons: Not everyone needs aggressive appetite suppression to improve metabolic health Some people are more sensitive to GLP-1 medications Side effects often increase with higher doses Cost and long-term sustainability matter Women, in particular, started asking different questions
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The combination of GLP-1, GIP and/or GCG agonist actions with amylin—through the incorporation of cagrisemaglutide or amicretin—opens the door to the development of new multiagonists as treatments for obesity, type 2 diabetes, and possibly other chronic diseases
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