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Pharmacogenetics of Glucagon-like-peptide-1 receptor in diabetes management

Clinical trials, including the SURPASS program, have shown that tirzepatide achieves greater reductions in body weight (up to 22.5%) and HbA1c levels compared to GLP-1 monotherapy with semaglutide [22, 23]

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With metabolic stress, leukocyte–endothelial interactions become more adhesive and pro-inflammatory, contributing to endothelial dysfunction, vascular stiffness, and atherosclerotic progression