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Thereby, an upregulation of CD68 occurs and initiates a signaling cascade, which might be implicated in the pathogenesis of arthritis, and may be relevant for other inflammatory diseases as well ( Another well-known interaction of DPP4 is with extracellular matrix proteins like collagen and fibronectin ( Potential Receptors for sDPP4 Since DPP4 is shedded from the membrane of cells with intact enzymatic and cysteine-rich region, it can also exert biological functions in a paracrine or endocrine manner
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doi: 10.1039/c5fo01530h
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