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Partial unwinding of the short α-helix elevates ECL1 to an extended conformation that stands upwards in line with TM2 and TM3, thereby engaging the C-terminal half of GLP-2 through an extensive interface spanning from Leu 14P to Trp 25P (Figs
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Therefore, comprehensive counseling should be provided to patients so that they understand the mechanisms of action of GLP-1 agonists, the potential for weight loss and its associated benefits, and the possible unintended consequences
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