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Additionally, sex-specific effects remain underexplored, as evidence suggests differential susceptibility to Epstein-Barr virus-driven AD in females 25 , and metformin has been reported to exert sex-specific effects on cognition, which may interact with DM2 DMTs in influencing AD risk

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The combined group showed a lower risk of MAKE than SGLT2i monotherapy (aHR = 0.70) and GLP-1RAs monotherapy (aHR = 0.45)