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But individuals starting semaglutide who are also dealing with GI side effects, reduced food and fluid intake, and the physiological stress of early dose escalation may notice this elevated baseline more acutely than someone in a controlled trial environment
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Across both preclinical models and human observational studies, GLP-1 RA therapy has frequently been associated with shifts toward a more eubiotic microbial configuration
![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are_Q320.jpg)
