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Cartilage has no blood vessels or nerves, and its cells divide very slowly, leaving it unable to heal itself on its own
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The correlation between the presence of this moiety and the requirement for an Epsin-dependent “pull” to induce the ADAM cleavage of the NRR in most systems led us to test whether the absence of this structural element in LIN-12 and GLP-1 might be responsible for the Epsin-independence of DSL/Notch signaling in C
