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Potential explanations include differences in the type of patients included, adherence to study treatment, sample size, duration of drug exposure, and GLP1 receptor activation with greater HbA1c reduction with longer-acting human GLP1-based analogs than with some short-acting exendin-4 analogs
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Interestingly, these observed bacteria which are decreased in abundance in DRE are all major producers of SCFAs (such as butyrate, propionate, and acetate) ( Table 1 Overview of previous studies (2017-2025) about gut microbiota in DRE
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