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e , NCI-H716 cells were treated with GPCR antagonists (10 μM) or vehicle (DMSO) for 15 min before P9 treatment (50 μg ml −1 ), then incubated for an additional 2 h, after which GLP-1 secretion was analyzed (n = 6 per group)

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The dose titration schedule for Wegovy spans 16–20 weeks, gradually increasing from 0.25 mg to the maintenance dose of 2.4 mg weekly

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