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Consider two people who both lose 15 kilograms on a GLP-1 drug: Lost 15 kg — but poorly 10 kg fat lost 5 kg muscle lost Metabolic rate has fallen Blood sugar control worsened Higher fall risk than before Weight regain likely — as fat Lost 15 kg — and well 14 kg fat lost 1 kg muscle lost (or neutral) Metabolic rate preserved Blood sugar control improved Strength maintained or increased Better long-term weight maintenance Both people lost the same amount of weight by the scale

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The Discovery of GLP-1 GLP-1 is part of the incretin family of hormones