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Epithelial lineage cells were further subdivided into ISC ( LGR5 + , OLFM4 + , ASCL2 + ), proximal progenitor ( FGG + , FGB + ), TA ( MKI67 + , TOP2A + , PCNA + ), Paneth ( DEFA5 + , DEFA6 + , REG3A + ), enterocyte precursor ( FABP2 + , APOA4-, RBP2 + ), enterocyte ( FABP2 + , APOA4 + , RBP2 + ), BEST4 enterocyte ( BEST4 + , OTOP2 + , CFTR + ), goblet ( MUC2 + , CLCA1 + , TFF3 + ), EEC ( CHGA + , NEUROD1 + ), and tuft ( POU2F3 + , LRMP + , TRPM5 + )