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While this study was only performed in relatively lean female mice, which are mostly protected against diet-induced obesity, it is in line with a study performed in patients receiving tirzepatide, dulaglutide, or placebo, which showed that tirzepatide treatment dose-dependently decreased levels of ApoC-III and ApoB and the number of large triglyceride-rich lipoprotein particles and small LDL particles, suggesting a net improvement in atherogenic lipoprotein profile (Wilson et al
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