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Skipping protein: Without enough protein, your body may break down muscle instead of fat, slowing metabolism and making it harder to sustain progress

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However, both medications can affect kidney function indirectly—metformin requires renal clearance and should be dose-adjusted or discontinued if eGFR falls below 30 mL/min/1.73m², while GLP-1 agonists can cause volume depletion through weight loss and reduced appetite, potentially stressing kidneys in individuals with baseline renal impairment