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Moving further along the kidney nephron, the GCGR is primarily expressed in the distal segments of the kidney (Fig
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A separate 2026 systematic review in the medical journal, The BMJ, found that weight returned at an average rate of about 0.4 kilograms — roughly one pound — per month after stopping weight-management medication, putting many patients on track to return to their starting weight within about 1.5 to 2 years without ongoing treatment
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