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Studies in rodents showed, for example, that GIPR agonism mediates weight-independent insulin sensitization by improving glucose disposal into white adipose tissue (WAT)
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The binding with M6P/IGF-IIR occurs via M6P residues in the carbohydrate moiety of DPP4 and the complex is then internalized and able to exert its biological function ( Our group showed that at least in human vascular smooth muscle cells, protease-activated receptor 2 (PAR2) might be activated by sDPP4
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