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Several studies have also shown that SCFAs, which are products of the fermentation of DF (including inulin), promote the proliferation of ILC3s and CD4 + T cells and subsequent production of IL-22 through several mechanisms (101, 102)
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Interrogation of the ATM data revealed specific proinflammatory transcripts, including the interferon response genes Gbp3 and Mx2 , CXCL chemokine family members ( Cxcl19 , Cxcl11 , Cxcl10 ), and C-C motif chemokine ligand 5 ( Ccl5 ), that were commonly upregulated in PAR2 mutants when compared with PAR2-WT mice (Supplemental Figure 7B)
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