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9,10 Summary ● A large body of high-quality evidence suggests that in patients with obesity without diabetes, GLP-1 and GIP/GLP-1 receptor agonists are associated with significant regain of lost weight after therapy discontinuation

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2 However, most of the current GLP-1 formulations have limitations that can affect patient adherence and treatment success, such as frequent injections, gastrointestinal side effects, inconsistent and low bioavailability, as well as high price