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The cell-permeable DPP-8/9 inhibitor 7 was chosen as a lead compound and deconstructed into different substructures that were modified individually to assess their ability to contribute to selectivity

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The Gut-Brain Axis and the Vagus Nerve The GLP-1 produced in the intestines after a meal also plays a role in suppressing eating, likely through different circuits than those GLP-1-expressing neurons found in the brain stem