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Surprisingly, glucagon, which is used to treat severe hypoglycemia by targeting the glucagon receptor and is a weak agonist for GLP-1R 26 , was also found to activate a subset of the pathways elicited by GLP-1 (7-36) stimulation 5 , underlining the importance of investigating polypharmacology

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Treatment with semaglutide 2.4 mg led to significant improvements in heart failure–related symptoms and physical functioning, as measured by KCCQ-CSS, along with meaningful reductions in body weight compared to placebo