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For some users, switching to an oral GLP-1 formulation eliminates injection site reactions entirely

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If we ignore the intestinal versus pancreatic source of GLP-1 topic and just focus on the fact that GLP-1 regulates insulin secretion by acting directly on β-cell GLP-1rs and either directly or indirectly suppresses glucagon then under what circumstance is glucagon important for β-cell GLP-1r signaling