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In addition to reducing the cholesterol content of plaque, lipid lowering reduces the accumulation of macrophages, which produce proteolytic enzymes, such as matrix metalloproteinases (MMPs, especially MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13) [13]

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If side effects are severe, your provider may recommend temporarily pausing dose escalation or reducing the dose according to the FDA-approved titration schedule