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PlexusDx recommends discussing your kidney function with your healthcare provider before starting creatine, especially if you are already on semaglutide

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[24] However, they do warn of gastrointestinal side effects, including “nausea, vomiting, diarrhea, abdominal pain, and constipation.” [25] The warnings for drugs manufactured by Eli Lilly, namely, Trulicity and Mounjaro, warn of gastroparesis and other severe gastrointestinal reactions