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8.3%, P 10%), despite twice-daily insulin administration, may show significant improvement in glycemic regulation and/or decrease in insulin daily dose of insulin-SU therapy.[129] Evidence suggests that addition of SUs to insulin in patients with uncontrolled glycemic levels reduces the insulin dose by 20%–30% and avoids hypoglycemia.[130] Therefore, studies have compared the treatments with a smaller insulin dose with SU and a larger insulin dose without SU

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Healthcare providers start the medication at a low dose and titrate slowly to reach higher doses