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This result may be related to insufficient sample size (Rizza et al., 2023)

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Components • Drug–receptor interaction • Dose–response relationship • Efficacy and potency • Therapeutic and toxic effects Examples • Morphine causes analgesia via μ-opioid receptors • Beta-blockers reduce heart rate by blocking β₁ receptors • PK = movement of drug • PD = effect of drug • Dose adjustment → pharmacokinetics • Drug response variation → pharmacodynamics • PK determines how much drug reaches site • PD determines what the drug does there To view or add a comment, sign in Drug–Drug Interactions (DDIs): Mechanisms Every Pharmacologist Should Know 👩🔬 Friend: “If two drugs are safe on their own, why can they become dangerous together?” Because drugs don’t act in isolation, they share the same biological systems