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These authors concluded that “the proportion of LBM relative to total body mass increased with semaglutide.” Similarly, in the SURMOUNT-1 trial which studied tirzepatide, researchers found that “participants treated with tirzepatide had a percent reduction in fat mass approximately 3 times greater than the reduction in lean mass, resulting in an overall improvement in body composition.” More recently, a viewpoint in JAMA re-grounded the conversation: weight loss in persons with obesity primarily reduces body fat, but also decreases fat free mass (FFM)

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Navigating symptoms and choosing the foods that will best support you can be challenging, but a Registered Dietitian Nutritionist can help