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This mechanism may increase the risk of internal irritation, especially in people with existing gastrointestinal conditions like inflammatory bowel disease or gastric ulcers

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Two unique compounds have been evaluated in Phase 2 trials (SAR425899 and MEDI0382), and although dual-agonism has produced promising results on body weight and glycemic control in diabetic patients [926,927], it is not apparent that these co-agonists are superior to selective GLP-1R agonists