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How weight-loss medications evolved from short-term tools to ongoing treatment The short-term era Before GLP-1s became the weight-loss drug du jour, there was fen-phen — a diet-drug craze whose name alone is enough to spark instant recognition, unease and a fair amount of “Wait, I can’t believe that was a thing.” The off-label combination paired phentermine with fenfluramine, both stimulants, and became widely used in the '90s
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