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There was a lot of conversation about Medicare and GLP-1 medications last week, and I understand why. For so many people, the biggest barrier to evidence-based treatment has never been lack of
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Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (α-aminoisobutyric acid (Aib)), but not recognized by the enzyme
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