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Disrupted sleep throws off these microbial rhythms, reducing the effectiveness of time-sensitive probiotic dosing and impairing gut barrier function overnight when repair processes normally peak

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Taken together, these limitations underscore the need for larger, multicenter randomized controlled trials with longer follow-up periods, standardized interventions, and biomarkers of smoking cessation such as Nicotine Metabolite Ratio [90] to more definitively establish the role of GLP-1 RAs in this context