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(2025), in a network meta-analysis of 22 RCTs (2,258 participants) published in Metabolism, reported a mean difference of −0.86 kg lean mass for GLP-1 receptor agonists versus placebo, corresponding to roughly 25% of total weight loss
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The findings were notable
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
