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12 , 36 , 38 Pharmacokinetic data in patients taking long-acting GLP-1 RAs support the presence of a significant drug blood concentration (equivalent to the peak of a lower GLP-1 RA dose) 5–7 days after a missed dose.87, 88, 89, 90 Therefore, discontinuation for a period of time less than three to five half-lives might not lead to complete restoration of gastrointestinal motility and gastric emptying

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Vascular biology of glucagon receptor superfamily peptides: mechanistic and clinical relevance