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Sections on the right side were incubated with Sniper (Biocare, BS966M) for 10 minutes and rabbit anti-somatostatin (anti-SST) (Agilent/Dako, A0566) diluted at 1:1,000 for 1 hour

Scotty Coats

Dose:0.25 mg

What tends to help in real life: Slower ramp and longer "holds" at each dose level Smaller meals, earlier dinner, and avoiding heavy fat portions close to bedtime (fat slows gastric emptying further) A plan for reflux management with your clinician if you already have GERD Based on available data, oral semaglutide is more likely to be the better tolerated oral choice than orforglipron for nausea-prone patients