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EAAs – histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine – are called “essential” because they cannot be produced endogenously, and thus must be consumed Glutamine is the most abundant amino acid in the human body
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Liraglutide exerts anti-catabolic effect in murine primary chondrocytes in vitro To explore the inhibitory effect of liraglutide on the production of catabolic mediators, IL-1β-stimulated chondrocytes were cultured with 2 ng/mL of IL-1β and 10 ascending doses (6.6, 13.3, 26.6, 53.1, 106.3, 212.5, 425, 850 nM, 1.7 and 3.4 µM) of liraglutide for 24 h for IC 50 determination
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